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If the penis becomes erect during the night, the bands stretch, measuring the changes in penile circumference. Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice variants. These unique PDEs differ in their three-dimensional structure, kinetic properties, modes of regulation, intracellular localization, cellular expression, and inhibitor sensitivities. Current data suggest that individual isozymes modulate distinct regulatory pathways in the cell. These properties therefore offer the opportunity for selectively targeting specific PDEs for treatment of specific disease states. The feasibility of these enzymes as drug targets is exemplified by the commercial and clinical successes of the erectile dysfunction drugs, sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). PDE inhibitors are also currently available or in development for treatment of a variety of other pathological conditions. In this review the basic biochemical properties, cellular regulation, expression patterns, and physiological functions of the different PDE isoforms will be discussed. How these properties relate to the current and future development of PDE inhibitors as pharmacological agents is especially considered. PDEs hold great promise as drug targets and recent research advances make this an exciting time for the field of PDE research. Adverse effects, including lethargy and drowsiness Prescribing and Price Ejaculation has two phases -- in the first, the vas deferens, the tubes that store and transport sperm from the testes, contract to squeeze the sperm toward the prostate gland and urethra and seminal vesicles release secretions that make semen. In the second phase, muscles at the base of penis contract every 0.8 seconds and force the semen out of the penis in up to five spurts. Penile biothesiometry: This test involves the use of electromagnetic vibration to determine sensitivity and nerve function. A decreased sensitivity to these vibrations may indicate nerve damage. Proteinuria Glycosuria Hypertriglyceridemia Hypogonadism Decreased libido; fatigue Bilateral testicular atrophy; scant body hair; gynecomastia Decreased morning free testosterone